Biochemistry | Alcohol Metabolism

🍐 In this episode of PodBites, Omar Luay and Abdallah Kharsa break down alcohol metabolism — following ethanol from absorption to breakdown, and explaining why this everyday substance causes such wide-ranging clinical effects.

🎙️ Tune in to explore:

• How alcohol is absorbed, distributed, and eliminated

• The two-step breakdown: ADH → acetaldehyde → ALDH

• Why acetaldehyde causes flushing and hangover symptoms

• The role of NADH excess in lactic acidosis and hypoglycemia

• MEOS (CYP2E1) and drug–alcohol interactions

• Genetic differences behind Asian flush syndrome

• Chronic alcohol complications: fatty liver, cirrhosis, and neurotoxicity

• Key clinical ties like thiamine deficiency and disulfiram

🌟 A high-yield, clinic-linked breakdown that turns alcohol metabolism from trivia into something you can actually reason through.